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KMID : 0359819950240080857
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Journal of Korean Neurosurgical Society
1995 Volume.24 No. 8 p.857 ~ p.863
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Immunohistochemical Study of Medulloblastomas and Cerebral Primitive Neuroectodermal Tumors
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Abstract
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Although it is becoming widely accepted that medulloblastoma and cerebral primitive neuroectodermal tumor (PNET) are identical tumors occuring at different locations. there are some controversies in their origin and pathological classification.
As
a
method of investigating whether the tumors are identical in pathological aspects. immunohistochemical characteristics of medulloblastomas and cerebral PNETs were compared in this study. Also the prognostic significance of the immunohistochemical
findings in medulloblastoma patients was analyzed.
Clinical features of twenty-seven patients with medulloblastoma and eleven patients with cerebral PNET were reviewed. excluding tumors with significant cellular differentiation such as ependymoblastoma. pineoblastoma and neuroblastoma. The
presence
of
glial fibrillary acidic protein (GFAP). neurofilament (NF). S-100 protein, vimentin, synaptophysin, and epithelial membrane antigen (EMA) was examined with immunohistochemical method and the differences of the results between the two tumors were
statistically analyzed.
The positive rates of NF and synaptophysin were significantly higher in medulloblastomas (p=0.006 and 0.003, respectively) and so was the positive rate of vimentin in cerebral PNETs (p=0.0004). S-100 protein showed a higher positive rate in
cerebral
PNETs although it was not statistically significant. Univariate and multivariate analyses did not show any significant correlation between the duration of survival and the presence of cellular antigens.
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KEYWORD
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